Detailed view for TVAG_004440

Basic information

TDR Targets ID: 920703
Trichomonas vaginalis, cyclophillin, putative
Source Database / ID: 

pI: 7.6695 | Length (AA): 173 | MW (Da): 19189 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129059)

Species Accession Gene Product
Arabidopsis thaliana AT2G15790   peptidyl-prolyl cis-trans isomerase CYP40
Candida albicans CaO19.7654   likely cyclophilin type peptidyl-prolyl cis-trans isomerase similar to S. cerevisiae CPR6 (YLR216C)
Dictyostelium discoideum DDB_G0283663   cyclophilin-type peptidylprolyl cis-trans isomerase
Drosophila melanogaster Dmel_CG8336   CG8336 gene product from transcript CG8336-RB
Entamoeba histolytica EHI_125840   peptidyl-prolyl cis-trans isomerase, putative
Homo sapiens ENSG00000171497   peptidylprolyl isomerase D
Leishmania braziliensis LbrM.34.4730   cyclophilin 40
Leishmania donovani LdBPK_354830.1   peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative
Leishmania infantum LinJ.35.4830   cyclophilin 40
Leishmania major LmjF.35.4770   cyclophilin 40
Leishmania mexicana LmxM.34.4770   peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative
Mus musculus ENSMUSG00000027804   peptidylprolyl isomerase D (cyclophilin D)
Oryza sativa 4330806   Os02g0761100
Oryza sativa 4340493   Os06g0216800
Saccharomyces cerevisiae YLR216C   peptidylprolyl isomerase CPR6
Trypanosoma brucei gambiense Tbg972.9.5630   peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative,cyclophilin-40, putative
Trypanosoma brucei Tb927.9.9780   peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative
Trypanosoma cruzi TcCLB.506885.400   40 kDa cyclophilin, putative
Trypanosoma cruzi TcCLB.503687.40   rotamase, putative
Trichomonas vaginalis TVAG_004440   cyclophillin, putative

Essentiality

TVAG_004440 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1350 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1350 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1350 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.1350 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens peptidylprolyl isomerase D Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cyclophilin A 164 aa 62.5% 168 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0064 0.3832 0.3832
0.00691212 0.5 0.5
0.0063 0.5 0.5
0.0329 0.5424 0.5424
0.0064 0.3832 0.3832
0.0056 0.3832 0.3832
0.0051 0.5 0.5
0.0277 0.3943 0.5873
0.0103 0.9952 0.9952
0.0052 1 1
0.0165 0.4849 0.4849
0.0112 0.2729 0.4935
0.0179 0.4616 0.4616
0.0063 0.4706 0
0.0064 0.3832 0.3832
0.0178 0.4623 0.4623
0.0181131 0.282723 0.282723
0.0064 0.3832 0.3832

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_004440 (Trichomonas vaginalis), cyclophillin, putative
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